From Protocol to Evidence in Six Phases

The most critical phase of any systematic review. If the protocol leaves room for interpretation, downstream AI and human decisions will be inconsistent. Puraite provides a guided wizard that walks you step by step through protocol creation – simply fill in the fields without having to set up the protocol manually. It flags ambiguous criteria in real time so every inclusion rule is precise before screening begins.

• Define Research Question (PICO)
• Conduct Scoping Search
• Write the Protocol
• Register Protocol (optional)

Create complex Boolean strings with controlled vocabulary (MeSH, Emtree), execute across PubMed, Embase and CENTRAL, hand-search trial registries and conference proceedings, then algorithmically deduplicate.

• Develop Search Strategy
• Execute Database Searches
• Search Grey Literature
• Deduplicate Records

Run screening manually, AI-assisted, or fully AI-driven. Assign multiple reviewers, track decisions by user, and resolve conflicts without leaving the platform.

• Title/Abstract Screening
• Resolve TIAB Conflicts
• Full-Text Retrieval
• Full-Text Screening
• Resolve Full-Text Conflicts

Support independent dual extraction, reviewer comments, PM oversight and structured conflict resolution, with or without AI assistance. Risk of bias is assessed with a number of different tools, licensed for academic and industry use.

• Design Extraction Form
• Extract Data (Dual)
• Risk of Bias Assessment
• Resolve Conflicts
• Contact Authors

Statistically combine data with forest plots, test heterogeneity, assess publication bias. Apply GRADE to evaluate evidence certainty. Generate standard Summary of Findings tables.

• Meta-Analysis
• Qualitative Synthesis
• GRADE Assessment
• Summary of Findings Tables

Write the final report adhering to PRISMA guidelines, generate the visual flow diagram mapping records at every phase and continuously monitor for new evidence.

• PRISMA Manuscript Draft
• PRISMA Flow Diagram
• Living Review Monitoring